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Xenon in PDB 4nwh: Lysozyme Under 30 Bar Pressure of Xenon

Enzymatic activity of Lysozyme Under 30 Bar Pressure of Xenon

All present enzymatic activity of Lysozyme Under 30 Bar Pressure of Xenon:
3.2.1.17;

Protein crystallography data

The structure of Lysozyme Under 30 Bar Pressure of Xenon, PDB code: 4nwh was solved by N.Colloc'h, T.Prange, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.65
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.306, 79.306, 38.072, 90.00, 90.00, 90.00
R / Rfree (%) 17.3 / 20.8

Other elements in 4nwh:

The structure of Lysozyme Under 30 Bar Pressure of Xenon also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Sodium (Na) 1 atom

Xenon Binding Sites:

The binding sites of Xenon atom in the Lysozyme Under 30 Bar Pressure of Xenon (pdb code 4nwh). This binding sites where shown within 5.0 Angstroms radius around Xenon atom.
In total 2 binding sites of Xenon where determined in the Lysozyme Under 30 Bar Pressure of Xenon, PDB code: 4nwh:
Jump to Xenon binding site number: 1; 2;

Xenon binding site 1 out of 2 in 4nwh

Go back to Xenon Binding Sites List in 4nwh
Xenon binding site 1 out of 2 in the Lysozyme Under 30 Bar Pressure of Xenon


Mono view


Stereo pair view

A full contact list of Xenon with other atoms in the Xe binding site number 1 of Lysozyme Under 30 Bar Pressure of Xenon within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Xe202

b:35.4
occ:0.15
OG1 A:THR43 3.3 13.8 1.0
CB A:THR43 3.9 12.9 1.0
O A:HOH310 3.9 28.5 1.0
C A:THR43 4.2 13.1 1.0
N A:ARG45 4.2 14.8 1.0
O A:THR43 4.3 15.6 1.0
N A:ASN44 4.3 13.1 1.0
CA A:ASN44 4.4 14.8 1.0
C A:ASN44 4.5 14.2 1.0
CG2 A:THR51 4.5 11.7 1.0
NH2 A:ARG68 4.6 19.5 1.0
CB A:ARG45 4.6 18.1 1.0
NE A:ARG45 4.7 21.4 0.5
CA A:THR43 4.7 12.5 1.0
CA A:ARG45 4.9 16.8 1.0
CG2 A:THR43 5.0 12.7 1.0
NH2 A:ARG45 5.0 23.1 0.5

Xenon binding site 2 out of 2 in 4nwh

Go back to Xenon Binding Sites List in 4nwh
Xenon binding site 2 out of 2 in the Lysozyme Under 30 Bar Pressure of Xenon


Mono view


Stereo pair view

A full contact list of Xenon with other atoms in the Xe binding site number 2 of Lysozyme Under 30 Bar Pressure of Xenon within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Xe203

b:28.3
occ:0.20
CG2 A:VAL92 3.4 17.4 1.0
CD1 A:LEU56 3.5 16.8 1.0
CE A:MET12 3.6 16.5 1.0
CG2 A:ILE55 3.7 17.0 1.0
CG A:LEU56 4.0 14.8 1.0
CD1 A:ILE88 4.1 18.6 1.0
N A:VAL92 4.1 13.8 1.0
CB A:SER91 4.1 14.2 1.0
CA A:VAL92 4.3 14.7 1.0
CB A:ILE88 4.4 17.9 1.0
C A:SER91 4.4 13.7 1.0
CB A:VAL92 4.5 16.0 1.0
CG A:MET12 4.5 15.7 1.0
CD1 A:LEU17 4.5 19.9 1.0
O A:ILE88 4.6 16.5 1.0
CG1 A:ILE88 4.7 17.9 1.0
O A:SER91 4.8 13.9 1.0
SD A:MET12 4.9 16.6 1.0
CG2 A:ILE88 4.9 18.0 1.0
CA A:SER91 5.0 13.6 1.0

Reference:

J.H.Abraini, G.Marassio, H.N.David, B.Vallone, T.Prange, N.Colloc'h. Crystallographic Studies with Xenon and Nitrous Oxide Provide Evidence For Protein-Dependent Processes in the Mechanisms of General Anesthesia Anesthesiology 2014.
ISSN: ESSN 1528-1175
PubMed: 25211169
DOI: 10.1097/ALN.0000000000000435
Page generated: Sat Oct 12 19:15:41 2024

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