Xenon in PDB 3plj: Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide

All present enzymatic activity of Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide:
1.7.3.3;

The structure of Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide, PDB code: 3plj was solved by G.Marassio, N.Colloc'h, T.Prange, J.H.Abraini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.99 / 1.73
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	80.354, 96.273, 105.577, 90.00, 90.00, 90.00
R / Rfree (%)	17.5 / 20.5

The structure of Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Xenon atom in the Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide (pdb code 3plj). This binding sites where shown within 5.0 Angstroms radius around Xenon atom.
In total 2 binding sites of Xenon where determined in the Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide, PDB code: 3plj:
Jump to Xenon binding site number: 1; 2;

Xenon binding site 1 out of 2 in the Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide


Mono view


Stereo pair view

A full contact list of Xenon with other atoms in the Xe binding site number 1 of Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide within 5.0Å range: probe atom residue distance (Å) B Occ A:Xe801 b:32.7 occ:0.60 N2 A:N2O803 0.4 33.0 0.4 O3 A:N2O803 1.2 31.2 0.4 N1 A:N2O803 1.2 32.7 0.4 CD1 A:LEU252 3.8 18.4 1.0 CG2 A:THR230 4.0 17.8 1.0 CB A:THR230 4.1 17.4 1.0 CD1 A:PHE219 4.1 19.5 1.0 CG1 A:VAL227 4.2 16.1 1.0 CD2 A:LEU178 4.2 20.0 1.0 O A:VAL227 4.3 14.8 1.0 CA A:VAL227 4.4 15.2 1.0 CE1 A:PHE219 4.4 18.4 1.0 CE A:MET234 4.5 20.2 1.0 CB A:VAL227 4.6 14.2 1.0 CG2 A:VAL227 4.6 15.1 1.0 CG2 A:THR180 4.7 16.1 1.0 N A:MET231 4.8 17.0 1.0 C A:VAL227 4.8 13.8 1.0 CG A:LEU178 4.9 17.0 1.0 OG1 A:THR230 5.0 17.2 1.0

Xenon binding site 2 out of 2 in the Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide


Mono view


Stereo pair view

A full contact list of Xenon with other atoms in the Xe binding site number 2 of Urate Oxidase Under 3.0 Mpa / 30 Bars Pressure of Equimolar Mixture Xenon : Nitrous Oxide within 5.0Å range: probe atom residue distance (Å) B Occ A:Xe802 b:31.9 occ:0.18 CE A:MET32 2.1 20.7 0.5 SD A:MET32 3.5 20.8 0.5 O A:VAL15 3.6 12.5 1.0 CG A:MET32 3.6 16.6 0.5 O A:TYR30 3.7 16.4 1.0 CG1 A:VAL15 3.8 17.4 1.0 SD A:MET32 3.8 22.0 0.5 N A:LYS17 3.9 13.0 1.0 C A:VAL15 4.0 12.7 1.0 CE A:MET32 4.0 22.7 0.5 CG2 A:VAL73 4.0 20.8 1.0 CB A:VAL15 4.0 14.8 1.0 CB A:LYS17 4.0 14.2 1.0 CB A:TYR30 4.1 16.1 1.0 CG1 A:VAL73 4.1 19.7 1.0 C A:TYR30 4.1 14.9 1.0 CG A:MET32 4.1 15.0 0.5 CB A:VAL73 4.2 18.6 1.0 C A:TYR16 4.2 12.3 1.0 CB A:MET32 4.3 13.8 1.0 CA A:TYR16 4.3 13.4 1.0 N A:MET32 4.3 11.1 1.0 N A:TYR16 4.4 12.7 1.0 CA A:GLU31 4.5 12.4 1.0 N A:GLU31 4.5 14.5 1.0 CA A:LYS17 4.6 14.6 1.0 C A:GLU31 4.6 12.6 1.0 CA A:VAL15 4.7 13.3 1.0 O A:TYR16 4.8 13.1 1.0 CA A:TYR30 4.8 15.4 1.0 CA A:MET32 5.0 12.8 1.0

G.Marassio, T.Prange, H.N.David, J.Sopkova-De Oliveira Santos, L.Gabison, N.Delcroix, J.H.Abraini, N.Colloc'h. Pressure-Response Analysis of Anesthetic Gases Xenon and Nitrous Oxide on Urate Oxidase: A Crystallographic Study. Faseb J. V. 25 2266 2011.
ISSN: ISSN 0892-6638
PubMed: 21421845
DOI: 10.1096/FJ.11-183046