Xenon in PDB 3pkh: Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon

All present enzymatic activity of Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon:
1.7.3.3;

The structure of Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon, PDB code: 3pkh was solved by G.Marassio, N.Colloc'h, T.Prange, J.H.Abraini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.49 / 1.71
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	80.346, 96.337, 105.624, 90.00, 90.00, 90.00
R / Rfree (%)	16.7 / 19.1

The structure of Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon also contains other interesting chemical elements:

Sodium

(Na)

1 atom

The binding sites of Xenon atom in the Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon (pdb code 3pkh). This binding sites where shown within 5.0 Angstroms radius around Xenon atom.
In total 2 binding sites of Xenon where determined in the Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon, PDB code: 3pkh:
Jump to Xenon binding site number: 1; 2;

Xenon binding site 1 out of 2 in the Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon


Mono view


Stereo pair view

A full contact list of Xenon with other atoms in the Xe binding site number 1 of Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon within 5.0Å range: probe atom residue distance (Å) B Occ A:Xe801 b:33.3 occ:1.00 CD1 A:LEU252 3.9 17.4 1.0 CG2 A:THR230 4.0 14.5 1.0 CD1 A:PHE219 4.0 16.1 1.0 CB A:THR230 4.1 15.3 1.0 CD2 A:LEU178 4.2 16.2 1.0 CG1 A:VAL227 4.3 12.4 1.0 CE1 A:PHE219 4.3 14.3 1.0 CE A:MET234 4.4 18.4 1.0 O A:VAL227 4.4 12.2 1.0 CA A:VAL227 4.5 12.1 1.0 CG2 A:THR180 4.6 12.8 1.0 CB A:VAL227 4.8 11.8 1.0 CG2 A:VAL227 4.8 13.3 1.0 N A:MET231 4.8 14.1 1.0 CG A:LEU178 4.9 13.8 1.0 OG1 A:THR230 4.9 15.5 1.0 C A:VAL227 5.0 11.4 1.0

Xenon binding site 2 out of 2 in the Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon


Mono view


Stereo pair view

A full contact list of Xenon with other atoms in the Xe binding site number 2 of Urate Oxidase Under 1.5 Mpa / 15 Bars Pressure of Xenon within 5.0Å range: probe atom residue distance (Å) B Occ A:Xe802 b:33.5 occ:0.20 CE A:MET32 2.0 18.3 0.5 SD A:MET32 3.3 18.5 0.5 CG A:MET32 3.5 13.5 0.5 O A:VAL15 3.6 10.3 1.0 CG1 A:VAL15 3.6 14.5 1.0 SD A:MET32 3.7 18.8 0.5 O A:TYR30 3.7 13.9 1.0 CG A:MET32 3.8 12.9 0.5 N A:LYS17 3.9 10.2 1.0 CE A:MET32 4.0 17.0 0.5 C A:VAL15 4.0 10.1 1.0 CG2 A:VAL73 4.0 18.1 1.0 CB A:VAL15 4.0 11.3 1.0 CB A:TYR30 4.0 13.3 1.0 CG1 A:VAL73 4.1 17.2 1.0 CB A:LYS17 4.1 11.2 1.0 CB A:VAL73 4.1 15.9 1.0 C A:TYR30 4.1 12.7 1.0 C A:TYR16 4.2 9.7 1.0 N A:MET32 4.3 9.4 1.0 CA A:TYR16 4.4 10.1 1.0 CB A:MET32 4.4 11.9 1.0 N A:TYR16 4.4 10.0 1.0 CA A:GLU31 4.5 10.4 1.0 N A:GLU31 4.6 11.1 1.0 C A:GLU31 4.7 9.9 1.0 CA A:LYS17 4.7 12.1 1.0 CA A:VAL15 4.7 10.9 1.0 CA A:TYR30 4.8 12.9 1.0 O A:TYR16 4.8 10.8 1.0 CA A:MET32 5.0 11.0 1.0

G.Marassio, T.Prange, H.N.David, J.Sopkova-De Oliveira Santos, L.Gabison, N.Delcroix, J.H.Abraini, N.Colloc'h. Pressure-Response Analysis of Anesthetic Gases Xenon and Nitrous Oxide on Urate Oxidase: A Crystallographic Study. Faseb J. V. 25 2266 2011.
ISSN: ISSN 0892-6638
PubMed: 21421845
DOI: 10.1096/FJ.11-183046